Need of Innovative Research in Herbal Pharmacotherapy for Better Therapeutic Efficacy and Safety -- A Review

Need for Innovations in Herbal Pharmacotherapy

  • Bushra Hina Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University
  • Ghazala Hafeez Rizwani
Keywords: herbal formulations, crude drugs, plant toxicology, herbal biopharmaceutics, herbal pharmacotherapy

Abstract

Use of traditional medicines has deep cited roots in history in order to provide relief to mankind from various illnesses. Since prehistoric times nature has been serving as the basic and strongest pillar of the health care system and provide foundation and search engine for the modern/conventional system of medicine and synthetic/allopathic medicines. This revolutionary development in the field of medicines almost substituted the use of traditional medicines in most of the countries. But in the current scenario due to ever increasing cost and side effects people are moving back toward the green pharmacy. Unfortunately less attention is paid towards the Pharmacovigilance of the crude drugs/herbal raw material as well as herbal medicinal products (HMPs) as compare to the allopathic medicines that are prepared in the Pharmaceutical industries. Moreover Scientific Research that has been done in this discipline usually focused on the natural product chemistry and isolation of the lead compounds from the traditional medicines. In the current scenario modern researches have been started focusing on the pharmacological action and standardization of herbs and herbal formulations. However there is an urgent need to done innovative researches in the field of herbal pharmacotherapy, herbal biopharmaceutics (pharmacodynamics and pharmacokinetics), herbal toxicology, herb- herb interactions especially in case of poly herbal formulations, Herbal Bioequivalence, and other efficacy and safety related issues. This modern approach will open new horizons in the field of modern herbal pharmaceutical products development hence better and safe means of herbal pharmacotherapy.

References

Tyler V.E, Brady L.R, Robbers J.E. Pharmacognosy, 10th edition 2009; pp.1-7,263,390,426,468

Trease and Evans Pharmacognosy (2009). 16th edition. Elsevier.

World Health Organization (WHO). Traditional medicines. 2008. Fact Sheet, N 134.

Robinsonson MM and Zhang X. WHO. The World Medicine situation 2011.Traditional Medicines: global situation, issues, and challenges. World Health Organization, Geneva. pp.1-3

World Health Organization (WHO). General guidelines for methodologies on Research and Evaluation of Traditional Medicines. 2000 World Health Organization Geneva

Hina B, Rizwani G-H, Naseem S. Determination of toxic metals in some Herbal Drugs through Atomic Absorption Spectroscopy. Pak.J. Pharm.Sci., 2011; 24 (3): 353-358

Hussain S, Malik F, Khalid N, Qayyum M.A and Riaz H. Alternative and Traditional Medicines Systems in Pakistan: History, Regulation, Trends, Usefulness, Challenges, Prospects and Limitations, A Compendium of Essays on Alternative Therapy, Dr. Arup Bhattacharya (Ed.), 2012.

Patwardhan B. WHO-CIPIH Study nine on TM, Draft Report. Traditional Medicine: Modern Approach for Affordable Global Health. Commission on Intellectual Property, Innovation and Public Health (CIPPIH), world health organization WHO Geneva. 2005: pp.41

Lewis M. E. Should we be concerned about herbal remedies. Journal of Ethnopharmacology, 2001; 75: pp.141-164

Pelkonen O, Xu Q, and Fan T. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J Tradit Complement Med. 2014; 4(1): 1–7.

Ernst E. Harmless herbs? A review of the recent literature. Am. J. Med. 1998; 104(2): pp.170-178.

NSF International Standard/American National Standard NSF/ANSI-173. Dietary supplement-Standard 173. Metal contaminants Acceptance levels. NSF International 2003: pp.2, 4, 5, 7, 10, 14, 18.

USP <232>. <232> Elemental impurities-Limits. The United states Pharmacopeial convention. Pharmacopeial Forum, 2010; 36(1): pp197-200.

Disch L, Drewe1 J, and Fricker G. Dissolution Testing of Herbal Medicines: Challenges and Regulatory Standards in Europe, the United States, Canada, and Asia

dx.doi.org/10.14227/DT240217P6 6 Dissolution Technologies MAY 2017

Blume HH, Schug BS. Biopharmaceutical characterisation of herbal medicinal products: Are in vivo studies necessary? European Journal of Drug Metabolism and Pharmacokinetics 2000; 25(1):41-8.

Yao H, Shao Q and Fan XS. Metabolite Profiling and Pharmacokinetics of Herbal Compounds Following Oral Administration of a Cardiovascular Multi-herb Medicine (Qishen Yiqi Pills) in Rat Yufeng Zhang§ , Peiying Shi§ , Current Drug Metabolism,2012; 13:510-523

Choi S, Oh D-S, Jerng UM. A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin. PLoS ONE 2017; 12(8): e0182794. https://doi.org/10.1371/journal.pone.0182794

Parmar V. Herbal medicines: Its toxic effects and drug interactions. The Indian anesthetist’s Forum. 2005 (www.theiaforum.org).

Zhou X ,Poon J , Kwan P , Zhang R , Wang Y ,Poon S , Liu B , and Sze D. Novel Two-Stage Analytic Approach in Extraction of Strong Herb-Herb Interactions in TCM Clinical Treatment of Insomnia D. Zhang and M. Sonka (Eds.): ICMB 2010, LNCS 6165, 2010: pp. 258–267,. Springer-Verlag Berlin Heidelberg 2010

Shi L,Tang X, Wang Q, Wang X. He P, Wang Q, Liu L, Liu X, Zhang Y. Investigating herb-herb interactions: The potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizome (Gancao) and Sophorae flavescentis radix (Kushen). Journal of Ethnopharmacology. 2015; 165: 243-250

Steinhoff B. Legal Requirements for the Control of Contaminants in Herbal Medicinal Products and Related Areas. 2011. AOAC International Workshop Erlangen BundesverbandderArzneimittel-Hersteller B.A.H.

First Inter- Ministerial Conference on Health and conference in Africa Libreville, Gabon August 2008 Proceedings (2008). Health security through Healthy Environments. Traditional and current Environmental risks to human Health. WHO, Republique Gabonaise, UNEP United Nations Environmental Programme © World Health Organization, WHO Regional Office for Africa 2009: pp.7, 8

UNEP Environmental Pollution and Impacts on Public Health: Based on a study by Njoroge G. Kimani in cooperation with United Nations Environment programme and the St. John Catholic Church, Korogocho, UNEP Urban Environment Unit, United Nations Environment programme.

www.unep.org/urban.../pdfs/dandorawastedump-reportsummary.pdf

World Health Organization (WHO). Health risks of heavy metals from long range trance boundary air pollution. Joint WHO/ Convention Task Force on the Health Aspects of Air Pollution, Scherfigheg 8 DK-2100 Copenhagen, Denmark, World Health Organization, 2007:pp.1, 2, 5, 24-34, 65-70.

Hina B, Rizwani GH, Shareef H, Mahmud S. Trace Metal Detection in Some Medicinal Plants Used in Respiratory Tract Diseases through Atomic Absorption Spectroscopy in Karachi. The Journal of Phytochemistry. Photon 2014;115: 276-285.

Hina B, Rizwani GH, Shareef H, and Ahmed M. Atomic absorption spectroscopic analysis of some pakistani herbal medicinal products used in respiratory tract infections. Pak.J. Pharm.Sci., 2012; 25 (1): 247-253

Hina B and Rizwani GH. Spectrophotometric Analysis of Heavy Metal in Two Miraculous Medicinal herbs belonging to Family Piperaceae. Spatula DD 2014; 4(4):199-2016 doi:10.5455/spatula.20141103125414

Denholm J. Complementary Medicine and Heavy Metal Toxicity in AustraliaWebmedCentraltoxicology2010;1(9):WMC00535http://www.webmedcentral.com//article_view/535

Friberg L, Nordbergs GF and Vouk VB. Hand book on the toxicology of metals. 1986; Vols.1 and 2, Amsterdam, Oxford: Elsevier Science Publishers B.V, New York, pp.vol 1: 7, 8 pp. vol 2: 44,130, 131, 132, 323, 324, and 325.

Caldas ED, Machado LL. Cadmium, mercury and lead in medicinal herbs in Brazil. Food and chemical toxicology. 2004; 42(4): pp.599-603.

Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, and Davis RB, et al.. Heavy metal contents of Ayurvedic Herbal medicine products. JAMA, 2004; 292(23): pp.2868-2873.

Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, and Paquin J, et al.,. Lead, mercury and arsenic in US- and India- manufactured Ayurvedic Medicines sold via the internet. JAMA, 2008; 300(8): pp.915-923.

Agency for Toxic Substances and Disease Registry, ATSDR. Public Health Statements. Arsenic 2007; CAS# 7440-38-2 http://www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf

Agency for Toxic Substances and Disease Registry, ATSDR. Public Health Statements. Cadmium 2008: CAS# 7440-43-9 http://www.atsdr.cdc.gov/ToxProfiles/tp5-c1-b.pdf

Gasser U, Klier B, Kuhn A.V, Steinhoff B. Current Findings on the Heavy Metal Content in Herbal Drugs. Pharmeuropa Scientific Notes 2009; 1: pp.37-50

De Stefano AJ, Zaidi K, Cecil TL, Giancaspro GI, and the USP Elemental Impurities Advisory Panel. Elemental Impurities- Information. Pharmacopeialforum, 2010;36(1): pp.298-305.

World Health Organization (WHO).WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues 2007.

Patwekar S.L, Arvind B.S, Manoj S.G, Snehal P.R, Ashwini P.P . Standardization of herbal drugs: An overview. The Pharma Innovation Journal 2015; 4(9): 100-104

Ernst E. Toxic heavy metals and undeclared drugs in Asian herbal medicines. Review. Trends Pharmacol. Sci., 2002; 23(3): pp.136-139.

Schwarz M. Safety in laboratory and regulatory services for herbal products. Heavy metals, mycotoxins, and pesticides in herbal drugs and extracts. Phytolab. GmbH and Co. KG, 2015.

Ernst E. Serious adverse effects of unconventional therapies for children and adolescence: A systemic review of recent evidence. Eur.J. Pediatr, 2003; 162(2): pp.72-80.

Hussin H.A. Article Continuing Pharmacy Education Adverse Effects of Herbs And Drug-Herbal Interactions. Malaysian Journal of Pharmacy 2001; 1(2):39-44 CPE

Staines S.S. Herbal medicines: adverse effects and drug-herb interactions. Journal of the Malta College of Pharmacy Practice, 2011; Issue 17, 38-42.

World Health Organization (WHO). Guidelines on good manufacturing practices (GMP) for herbal medicines. World Health Organization 2007

Good Agraicultural and Field collection Practices for Medicinal Plants. Drugs Control and Traditional Medicines. Aim Sion National Institute of Health Islamabad 45500 Pakistan.

World Health Organization (WHO). Guidelines on good agricultural and collection practices (GACP) for medicinal plants World Health Organization Geneva 2003.

Chen S, Yao H, Han J, Liu C, Song J, Shi L, et al. Validation of the ITS2 Region as a Novel DNA Barcode for Identifying Medicinal Plant Species. PLoS ONE 2010; 5(1): e8613. https://doi.org/10.1371/journal.pone.0008613

Gao T, Yao H, Song J, Liu C, Zho Y, Ma X, Pang X, Xu H, Chen S Identification of medicinal plants in the family Fabaceae using a potential DNAbarcode ITS 2. journal of Ethnopharmacology 2010; vol 130 (1): 116-121

Techen N, Parveen I, Pan Z, Khan IA (. DNA barcoding of medicinal plants material for identification. Current opinion in Biotechnology. 2014; 25:103-110

Chakraborty P. Herbal genomics as tools for dissecting new metabolic pathways of unexplored medicinal plants and drug discovery. Bio chimie open. 2018; vol6: 9-16

Published
2020-02-24
How to Cite
Hina, B., & Rizwani, G. (2020). Need of Innovative Research in Herbal Pharmacotherapy for Better Therapeutic Efficacy and Safety -- A Review. Annals of Jinnah Sindh Medical University, 5(2), 93-98. Retrieved from http://www.ajsmu.com/index.php/AJSMU/article/view/53