Cytopathological Spectrum of Pleural Fluid Effusion at a Tertiary Care Hospital of Karachi

Cytopathological spectrum spectrum of pleural effusion

  • Syed Mehmood Hasan Sindh Medical College, Jinnah Sindh Medical University
  • Asma Shabbir Sindh Medical College, Jinnah Sindh Medical University
  • Nazish Jaffar Sindh Medical College, Jinnah Sindh Medical University
  • Syed Muhammad Hasan Department of Medicine, Dow University of Health Sciences
Keywords: Pleural effusion, inflammatory cells, adenocarcinoma, atypical cells.


Objective: The aim of this study was to evaluate the spectrum of pleural fluid effusion for the period of one year received at tertiary care centre of Karachi.

 Methodology: This descriptive study was conducted after ethical approval at Burhani hospital laboratory, Karachi. Data of cytopathologically diagnosed peural fluid effusion was collected from the records available between June 2018 – June 2019. Relevant data pertaining registration number, age, gender of the patients and diagnosis were recorded. Data was entered and analysed using SPSS version 21

Results: Of the total 59 cases received, 44 (74.4%) were males & 12 (25.5%) were females. Age range was between 35 – 70 years with mean value = 55±12.8. From 59 cases, 15 (25.4%) were mixed inflammatory infiltrate, 12 (20.3%) showed chronic inflammatory cells, 08 (13.5%) had predominantly neutrophils, 06 (10%) with atypical cells, 04 (6.7%) presented with adenocarcinoma and 14 (23.7%) were labelled as inadequate/haemorrhagic samples.

Conclusion: Majority of the pleural effusion samples were adequate. Inflammatory lesions were more common in comparison to malignancy.  Adenocarcinoma was the most common neoplastic entity. Pleural fluid cytology is an effective initial diagnostic modality in Pakistani health care setup.

Keywords: Pleural effusion, inflammatory cells, adenocarcinoma, atypical cells.


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How to Cite
Hasan, S., Shabbir, A., Jaffar, N., & Hasan, S. (2023). Cytopathological Spectrum of Pleural Fluid Effusion at a Tertiary Care Hospital of Karachi. Annals of Jinnah Sindh Medical University, 9(2), 38-41. Retrieved from
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